Oxidized Phospholipids as Endogenous Pattern Recognition Ligands in Innate Immunity
نویسندگان
چکیده
منابع مشابه
Oxidized phospholipids as endogenous pattern recognition ligands in innate immunity.
One of the major functions of the innate immune system is the surveillance of host tissues, identifying apoptotic and senescent cells for engulfment and orderly removal by macrophages (1,2). Macrophage recognition of modified lipoproteins occurs via similar pathways of the innate immune system, involving shared scavenger receptors and molecular pattern recognition ligands (3-6). These critical ...
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O consequence of living in an aerobic environment is an inexorable oxidative modification of molecular targets in vivo. At the cellular level the effects of the oxidized lipid and lipoprotein byproducts can include leukocyte recruitment, activation, and apoptosis. Accumulating at sites of inf lammation, these oxidation products can have profound pathological consequences, such as in the case of...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.r700054200